PROCAIN: protein profile comparison with assisting information
نویسندگان
چکیده
منابع مشابه
PROCAIN: protein profile comparison with assisting information
Detection of remote sequence homology is essential for the accurate inference of protein structure, function and evolution. The most sensitive detection methods involve the comparison of evolutionary patterns reflected in multiple sequence alignments (MSAs) of protein families. We present PROCAIN, a new method for MSA comparison based on the combination of 'vertical' MSA context (substitution c...
متن کاملPROCAIN server for remote protein sequence similarity search
UNLABELLED Sensitive and accurate detection of distant protein homology is essential for the studies of protein structure, function and evolution. We recently developed PROCAIN, a method that is based on sequence profile comparison and involves the analysis of four signals--similarities of residue content at the profile positions combined with three types of assisting information: sequence moti...
متن کاملFORTE: a profile-profile comparison tool for protein fold recognition
We present FORTE, a profile-profile comparison tool for protein fold recognition. Users can submit a protein sequence to explore the possibilities of structural similarity existing in known structures. Results are reported via email in the form of pairwise alignments.
متن کاملAn assessment of substitution scores for protein profile-profile comparison
MOTIVATION Pairwise protein sequence alignments are generally evaluated using scores defined as the sum of substitution scores for aligning amino acids to one another, and gap scores for aligning runs of amino acids in one sequence to null characters inserted into the other. Protein profiles may be abstracted from multiple alignments of protein sequences, and substitution and gap scores have be...
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OBJECTIVE Health information retrieval (HIR) on the Internet has become an important practice for millions of people, many of whom have problems forming effective queries. We have developed and evaluated a tool to assist people in health-related query formation. DESIGN We developed the Health Information Query Assistant (HIQuA) system. The system suggests alternative/additional query terms re...
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ژورنال
عنوان ژورنال: Nucleic Acids Research
سال: 2009
ISSN: 1362-4962,0305-1048
DOI: 10.1093/nar/gkp212